A new sensitive, specific, linear, precise and accurate RP-HPLC method was developed and validated for estimation of Quetiapine fumarate in Bulk and Tablet dosage form. An isocratic, reversed phase HPLC method was developed. Shimadzu shim pack C18(150mm x 4.5µm, x 5µ) column. Shimadzu Prominence-I LC-2030C plus equipped with Auto sampler as the instrument model. Mobile phase consists of mixture of Acetonitrile: 0.1% Ortho phosphoric acid in Millipore water v/v: Methanol in the ratio (60:30:10 v/v) at a flow rate of 0.8mL /min with injection volume of 20µL. UV detection was performed at 252nm. The Linearity was established for Quetiapine fumarate in the range of 2-12µg/ml with correlation coefficient of 0.997. LOD and LOQ were found to be 1.053µg/ml and 1.161µg/ml respectively. Retention time of Quetiapine fumarate were found to be 3.4mins. % Recovery was found to be 98.99-100.5 and %RSD was found with in ± 2. The method has been validated according to ICH guidelines for linearity, precision, accuracy, robustness, ruggedness, LOD and LOQ. The developed validated method was successfully applied for reliable quantification of Quetiapine fumarate in bulk and pharmaceutical dosage form.

A simple, rapid, precise, sensitive and reproducible reverse phase high performance liquid chromatography (RP-HPLC) method has been developed for the quantitative analysis of Remogliflozin Etabonate in pharmaceutical dosage form. Chromatographic separation of Remogliflozin Etabonate was achieved on Waters Alliance-e2695, by using Luna Phenyl Hexyl (150x4.6mm, 3.5µ) column and the mobile phase containing Acetonitrile and Ammonium formate pH-3.0 in the ratio of 70:30% v/v. The flow rate was 1.0ml/min; detection was carried out by absorption at 275nm using a photodiode array detector at ambient temperature. LOD and LOQ were found to be 0.30µg/ml and 1µg/ml respectively and retention time was found to be 2.271 mins. The % Recovery was found to be 99.83%. The number of theoretical plates and tailing factor for Remogliflozin Etabonate were NLT 2000 and not more than 2 respectively. % Relative standard deviation of peak areas of all measurements always less than 2.0. The proposed method was validated according to ICH guidelines. The method was found to be simple, economical, suitable, precise, accurate and robust method for quantitative analysis of Remogliflozin Etabonate.

In this article, the geometry dependent resistance model is developed to determine the effective thermal conductivity of the unit cell-based two-phase materials. The isotherm approach is used to develop the algebraic equations for the two-dimensional spatially periodic medium. The hexagon and octagon cylinders which form the geometry of the medium are arranged in a matrix of in-line, touching and non-touching. The several two-phase materials' thermal conductivity has been estimated by the proposed models (conductivity ratio varying from 1.812 to 398.7 and concentration between 0.2 and 0.866). Two-phase materials' estimated effective thermal conductivity is compared with predicted values of standard model. Estimated values of two-phase materials have also been compared with experimental values.