A simple, rapid, precise, sensitive and reproducible Ultra Fast high performance liquid chromatography (UF-HPLC) method has been developed for the quantitative analysis of Ezetimibe in pharmaceutical dosage form. Chromatographic separation of Ezetimibe was achieved on Prominence LC-20A Quaternary Gradient HPLC system,by using Shimpack C-18 5µm4.6×250mm column and the mobile phase containingAcetonitrile and 25Mm potassium hydrogen orthophosphate with pH 4.0 in the ratio 70:30 v/v. The flow rate was 1.0ml/min; detection was carried out by absorption at 232nm using a UV detector at ambient temperature. LOD and LOQ were found to be 0.0004148µg/ml and 0.0004298µg/ml respectively and retention time was found to be 5.4mins. The % Recovery was found to be 100.93%. The number of theoretical plates and tailing factor for Ezetimibe were NLT 2000 and not more than 2 respectively. % Relative standard deviation of peak areas of all measurements always less than 2.0. The proposed method was validated according to ICH guidelines. The method was found to be simple, economical, suitable, precise, accurate and robust method for quantitative analysis of Ezetimibe